bet eventually we'll find the same sort of
thing with the tonsils and men's foreskin."
Some scientists think they have figured
out the real job of the troublesome and seemingly useless appendix:
It produces and protects good germs for your gut.
That's the theory from surgeons and immunologists at Duke University
Medical School, published online in a scientific journal this
For generations the appendix has been dismissed as superfluous.
Doctors figured it had no function. Surgeons removed them routinely.
People live fine without them.
And when infected the appendix can turn deadly. It gets inflamed
quickly and some people die if it isn't removed in time. Two years
ago, 321,000 Americans were hospitalized with appendicitis, according
to the Centers for Disease Control and Prevention.
The function of the appendix seems related to the massive amount
of bacteria populating the human digestive system, according to
the study in the Journal of Theoretical Biology. There are more
bacteria than human cells in the typical body. Most of it is good
and helps digest food.
But sometimes the flora of bacteria in the intestines die or are
purged. Diseases such as cholera or amoebic dysentery would clear
the gut of useful bacteria. The appendix's job is to reboot the
digestive system in that case.
The appendix "acts as a good safe house for bacteria,"
said Duke surgery professor Bill Parker, a study co-author. The
location of the appendix -- just below the normal one-way flow
of food and germs in the large intestine in a sort of gut cul-de-sac
-- helps support the theory, he said.
Also, the worm-shaped organ outgrowth acts like a bacteria factory,
cultivating the good germs, Parker said.
That use is not needed in a modern industrialized society, Parker
said. If a person's gut flora dies, they can usually repopulate
it easily with germs they pick up from other people, he said.
But before dense populations in modern times and during epidemics
of cholera that affected a whole region, it wasn't as easy to
grow back that bacteria and the appendix came in handy.
In less developed countries, where the appendix may be still useful,
the rate of appendicitis is lower than in the U.S., other studies
have shown, Parker said.
The appendix, which is about two to four inches long, may be another
case of an overly hygienic society triggering an overreaction
by the body's immune system, he said.
Even though the appendix seems to have a function, people should
still have them removed when they are inflamed because it could
turn deadly, Parker said. About 300 to 400 Americans die of appendicitis
each year, according to the CDC.
Five scientists not connected with the research said that the
Duke theory makes sense and raises interesting questions.
The idea "seems by far the most likely" explanation
for the function of the appendix, said Brandeis University biochemistry
professor Douglas Theobald. "It makes evolutionary sense."
The theory led Gary Huffnagle, a University of Michigan internal
medicine and microbiology professor, to wonder about the value
of another body part that is often yanked: "I'll bet eventually
we'll find the same sort of thing with the tonsils." --
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